Whole-brain gray matter maturation trajectories associated with autistic traits from adolescence to early adulthood - Fondation pour la Recherche Médicale
Article Dans Une Revue Brain Structure and Function Année : 2023

Whole-brain gray matter maturation trajectories associated with autistic traits from adolescence to early adulthood

1 ICM - Institut du Cerveau = Paris Brain Institute
2 CHU Pitié-Salpêtrière [AP-HP]
3 IMN - Institut des Maladies Neurodégénératives [Bordeaux]
4 ERL Inserm U1299 - Trajectoires développementales en psychiatrie : mesures et modélisations
5 Hôpital Necker - Enfants Malades [AP-HP]
6 Imagine - U1163 - Imagine - Institut des maladies génétiques (IHU)
7 Nantes Univ - UFR MEDECINE - Nantes Université - UFR de Médecine et des Techniques Médicales
8 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
9 Fondation FondaMental [Créteil]
10 Central Institute of Mental Health [Mannheim]
11 Universität Heidelberg [Heidelberg] = Heidelberg University
12 King‘s College London
13 Trinity College Dublin
14 NEUROSPIN - Service NEUROSPIN
15 University of Vermont [Burlington]
16 UON - University of Nottingham, UK
17 Freie Universität Berlin
18 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
19 HU Berlin - Humboldt-Universität zu Berlin = Humboldt University of Berlin = Université Humboldt de Berlin
20 BIH - Berlin Institute of Health
21 PTB - Physikalisch-Technische Bundesanstalt [Braunschweig]
22 CB - CB - Centre Borelli - UMR 9010
23 EPS Barthélemy Durand [Etampes]
24 CAU - Christian-Albrechts-Universität zu Kiel = Christian-Albrechts University of Kiel = Université Christian-Albrechts de Kiel
25 Heidelberg University Hospital [Heidelberg]
26 UKE - Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg]
27 TU Dresden - Technische Universität Dresden = Dresden University of Technology
28 Fudan University [Shanghai]
Arun L.W. Bokde
Antoine Grigis
  • Fonction : Auteur

Résumé

Abstract A growing number of evidence supports a continued distribution of autistic traits in the general population. However, brain maturation trajectories of autistic traits as well as the influence of sex on these trajectories remain largely unknown. We investigated the association of autistic traits in the general population, with longitudinal gray matter (GM) maturation trajectories during the critical period of adolescence. We assessed 709 community-based adolescents (54.7% women) at age 14 and 22. After testing the effect of sex, we used whole-brain voxel-based morphometry to measure longitudinal GM volumes changes associated with autistic traits measured by the Social Responsiveness Scale (SRS) total and sub-scores. In women, we observed that the SRS was associated with slower GM volume decrease globally and in the left parahippocampus and middle temporal gyrus. The social communication sub-score correlated with slower GM volume decrease in the left parahippocampal, superior temporal gyrus, and pallidum; and the social cognition sub-score correlated with slower GM volume decrease in the left middle temporal gyrus, the right ventromedial prefrontal and orbitofrontal cortex. No longitudinal association was found in men. Autistic traits in young women were found to be associated with specific brain trajectories in regions of the social brain and the reward circuit known to be involved in Autism Spectrum Disorder. These findings support both the hypothesis of an earlier GM maturation associated with autistic traits in adolescence and of protective mechanisms in women. They advocate for further studies on brain trajectories associated with autistic traits in women.
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hal-04471170 , version 1 (20-09-2024)

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Guillaume Gros, Ruben Miranda Marcos, Anthony Latrille, Ana Saitovitch, Fanny Gollier-Briant, et al.. Whole-brain gray matter maturation trajectories associated with autistic traits from adolescence to early adulthood. Brain Structure and Function, 2023, 229 (1), pp.15-29. ⟨10.1007/s00429-023-02710-2⟩. ⟨hal-04471170⟩
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